C: Use with caution if Added benefits outweigh risks. Animal scientific tests demonstrate threat and human reports not offered or neither animal nor human reports carried out.

pentobarbital will minimize the level or impact of eletriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. The efficacy of hormonal contraceptives could be decreased.

pentobarbital will decrease the level or outcome of finasteride by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

Estradiol valerate/dienogest really should not be made use of for a minimum of 28 days right after discontinuation from the inducer because of possibility of lessened contraceptive efficacy.

Comment: Barbiturates may well raise adverse effects, such as respiratory melancholy, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of read more TCAs.

Contraindicated (1)pentobarbital will lessen the level or impact of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers may result in lowered serum concentrations and lack of antimalarial efficacy

pentobarbital will reduce the level or influence of ramelteon by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Significance Not known.

pentobarbital will decrease the extent or effect of piroxicam by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.

pentobarbital will lower the level or influence of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. If coadministration with a CYP3A4 inducer is important, look at raising oliceridine dose till secure drug effects are obtained; watch for signs of opioid withdrawal.

pentobarbital will lessen the level or influence of terbinafine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will minimize the level or influence of paclitaxel protein certain by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.

pentobarbital will reduce the level or influence of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will decrease the extent or outcome of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.